This 2019 article reviewed existing research and included laboratory experiments examining how pulsed electromagnetic field (PEMF) therapy may affect inflammation and tissue regeneration. In human stem/stromal cells, macrophage-like cells, and mouse muscle cells, PEMF exposure reduced several pro-inflammatory signals, including IL-1β, IL-6, IL-17A, TNF-α, and NF-κB activity. It also helped stabilize or increase certain anti-inflammatory signals involved in restoring cellular balance.
The researchers suggest that PEMF may influence cell-membrane ion channels, calcium activity, and other signaling pathways that regulate inflammation and repair. However, the experiments were conducted primarily in cultured cells—not patients—and PEMF did not significantly increase muscle-cell growth or myotube formation in this study. Additional clinical research is needed to confirm its effects in people and determine the most effective treatment settings.
In other words, PEMF therapy may help cells “turn down” signals associated with excessive inflammation while supporting signals that help the body return to a balanced state. This could create a cellular environment that is more favorable for healing and tissue repair.
